Spray Drying of Trehalose Solution, Spray Dryer for β-Cyclodextrin, Mumbai, India

Spray Drying of Trehalose Solution

Spray drying is a widely used technique in the field of food and pharmaceutical industries to convert liquid solutions or suspensions into solid powder form. It involves the atomization of a liquid feed into small droplets, which are then dried rapidly in a hot air stream. This process is particularly useful for heat-sensitive substances that cannot withstand high temperatures for prolonged periods.

Trehalose is a naturally occurring disaccharide found in a variety of organisms, including bacteria, fungi, and plants. It is widely recognized for its exceptional stability and preservation properties, making it a valuable ingredient in various applications such as food, cosmetics, and pharmaceuticals. Spray drying has been employed as a heat treatment method for trehalose solutions to produce trehalose powder.

The spray drying process of trehalose solution involves several stages. Initially, a trehalose solution is prepared by dissolving trehalose in a suitable solvent or water to form a homogeneous liquid. The concentration of the solution can vary depending on the desired final product characteristics.

The trehalose solution is then fed into a spray dryer, where it is atomized into fine droplets using high-pressure nozzles or other atomization devices. The droplets are then exposed to a stream of hot air in the drying chamber of the spray dryer. The hot air rapidly evaporates the solvent or water present in the droplets, resulting in the formation of solid trehalose particles. During the drying process, the heat-sensitive trehalose undergoes various physical and chemical transformations. The exposure to the high temperature causes the trehalose molecules to lose their water molecules, leading to the formation of an amorphous trehalose powder. The amorphous form of trehalose possesses enhanced stability and better solubility compared to its crystalline counterpart.

The operating parameters of the spray drying process, such as inlet air temperature, feed rate, and nozzle configuration, play a crucial role in determining the final product characteristics. Careful optimization of these parameters is necessary to achieve desired particle size, morphology, and powder flow properties.


The spray drying heat treatment of trehalose solution offers several advantages. Firstly, it allows for the production of trehalose powder with improved stability and prolonged shelf life. The amorphous structure obtained during spray drying helps to protect the trehalose from degradation and moisture absorption. Additionally, the powder form facilitates handling, transportation, and formulation of trehalose in various applications.

Kerone, Spray drying heat treatment of trehalose solution is an effective method to convert liquid trehalose into a stable and easily manageable powder form. This process allows for the preservation of trehalose's desirable properties while overcoming the challenges associated with its heat sensitivity. The resulting trehalose powder finds extensive use in food, pharmaceutical, and cosmetic industries for a wide range of applications.

  • Food Industry
  • Pharmaceutical Industry
  • Cosmetics and Personal Care Products
  • Biotechnology and Bioengineering
  • Nutraceuticals and Dietary Supplements
  • Preservation of Trehalose Properties
  • Enhanced Stability
  • Improved Solubility
  • Easy Handling and Formulation
  • Customizable Particle Size and Morphology
  • Improved Flow Properties
  • Versatile Applications